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KMID : 1040420190230020093
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Childhood Kidney Diseases
2019 Volume.23 No. 2 p.93 ~ p.99
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Pathology of C3 Glomerulopathy
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Shin Su-Jin
Seong Yoon-Je
Lim Beom-Jin
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Abstract
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C3 glomerulopathy is a renal disorder involving dysregulation of alternative pathway complement activation. In most instances, a membranoproliferative pattern of glomerular injury with a prevalence of C3 deposition is observed by immunofluorescence microscopy. Dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) are subclasses of C3 glomerulopathy that are distinguishable by electron microscopy. Highly electron-dense transformation of glomerular basement membrane is characteristic of DDD. C3GN should be differentiated from post-infectious glomerulonephritis and other immune complex-mediated glomerulonephritides showing C3 deposits.
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KEYWORD
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C3 glomerulopathy, C3 glomerulonephritis, Membranoproliferative glomerulonephritis, Dense deposit disease, Alternative complement pathway
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